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Impact of the Respiratory Motion and Longitudinal Profile on Helical Tomotherapy
Prog. Med. Phys. 2018;29(1):1-7
Published online March 31, 2018
© 2018 Korean Society of Medical Physics.

So Hyun Park, Jinhyun Choi*, JinSung Kim, Sohyun Ahn, Min Joo Kim, Ho Lee, Seo Hee Choi, Kwangwoo Park

Department of Radiation Oncology, Jeju National University Hospital, Jeju University College of Medicine, Jeju, Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
Correspondence to: Kwangwoo Park(
Tel: 82-2-2258-4362
Fax: 82-2-2227-7823
Received March 14, 2018; Revised March 15, 2018; Accepted March 19, 2018.
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The TomoTherapy® beam-delivery method creates helical beam-junctioning patterns in the dose distribution within the target. In addition, the dose discrepancy results in the particular region where the resonance by pattern of dose delivery occurs owing to the change in the position and shape of internal organs with a patient's respiration during long treatment times. In this study, we evaluated the dose pattern of the longitudinal profile with the change in respiration. The superior-inferior motion signal of the programmable respiratory motion phantom was obtained using AbChes as a four-dimensional computed tomography (4DCT) original moving signal. We delineated virtual targets in the phantom and planned to deliver the prescription dose of 300 cGy using field widths of 1.0 cm, 2.5 cm, and 5.0 cm. An original moving signal was fitted to reflecting the beam delivery time of the TomoTherapy®. The EBT3 film was inserted into the phantom movement cassette, and static, without the movement and with the original movement, was measured with signal changes of 2.0 s, 4.0 s, and 5.0 s periods, and 2.0 mm and 4.0 mm amplitudes. It was found that a dose fluctuation within ±4.0% occurred in all longitudinal profiles. Compared with the original movement, the region of the gamma index above 1 partially appeared within the target and the border of the target when the period and amplitude were changed. Gamma passing rates were 95.00% or more. However, cases for a 5.0 s period and 4.0 mm amplitude at a field width of 2.5 cm and for 2.0 s and 5.0 s periods at a field width of 5.0 cm have gamma passing rates of 92.73%, 90.31%, 90.31%, and 93.60%. TomoTherapy® shows a small difference in dose distribution according to the changes of period and amplitude of respiration. Therefore, to treat a variable respiratory motion region, a margin reflecting the degree of change of respiration signal is required. 
Keywords : TomoTherapy®, 4D CT, Moving phantom, Period, Amplitude

March 2018, 29 (1)