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Korean Journal of Medical Physics 2010; 21(4): 348-353

Published online December 25, 2010

Copyright © Korean Society of Medical Physics.

Imaging Studies in Mouse Brain Using Clinical 3T MRI Scanner

임상용 3T MRI를 이용한 마우스 뇌의 영상

Soo Mee Lim*, Eun-Mi Park

임수미*ㆍ박은미

Departments of *Radiology, Pharmacology, Ewha University Mokdong Hospital, School of Medicine, Ewha Womans University, Seoul, Korea

이화여자대학교 의학전문대학원 이대목동병원 *영상의학과, 약리학교실

Abstract

The purpose of this study was to explore the potentials of a clinical 3T MRI in mouse brains and technical adaptation and optimization. T1-weighted images (T1WI), T2-weighted images (T2WI), FLAIR (Fluid Attenuated Inversion Recovery) images, Gadolinium enhanced T1-weighted images (Gd-T1WI), Diffusion weighted images (DWI) were acquired in brain of 2 mice (weight 20∼25 g) with cerebral infarction by occlusion of right middle cerebral artery, 1 hour, 24 hours, 72 hours after infarction and 1 normal mouse brain using clinical 3T MRI scanner. We analyzed differentiation of striatum, ventricle, cerebral cortex, and possibility of detection of acute cerebral infarction. We could differentiate the striatum, ventricle, cerebral cortex on T2WI and on DWI, FLAIR, T1WI, the differentiation of each anatomy of brain was not definite, but acute cerebral infarction was detected on DWI of 1 hour, 24 hours, 72 hours after infarction and on T2WI, FLAIR of 24 hours, 72 hours after infarction. Clinical 3T MRI can be used in differentiation of anatomy of mouse brains and DWI can be helpul in detection of acute cerebral infarction in acute phase. With technical adaptation and optimization clinical 3T MRI can be useful tool for provide preclinical and clinical small animal studies.

KeywordsMagnetic resonance imaging (MRI), Small animal, Brain, Imaging diagnosis

Korean Society of Medical Physics

Vol.35 No.1
March 2024

pISSN 2508-4445
eISSN 2508-4453
Formerly ISSN 1226-5829

Frequency: Quarterly

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