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Original Article

Korean Journal of Medical Physics 2005; 16(4): 192-201

Published online December 25, 2005

Copyright © Korean Society of Medical Physics.

Impact of Contrast Agent for PET Images with CT-based Attenuation Correction

CT 영상을 이용한 감쇠 보정 시 조영제가 PET 영상에 미치는 영향

Hye-Kyung Son*, Timothy G. Turkington, Yun-Young Kwon*, Haijo Jung*, Hee-Joung Kim*§

손혜경*·Turkington Timothy G.·권윤영*·정해조*·김희중*§

*Research Institute of Radiological Science, Yonsei University, Department of Radiology, Duke University Medical Center, BK21 Project for Medical Science, §Department of Radiology, Yonsei University College of Medicine

*연세대학교 의과대학 방사선의과학연구소, DUKE 대학병원 진단방사선과, 연세대학교 의과대학 BK21 의과학사업단, §영상의학과

Abstract

Experiments and simulation were done to study the impact of contrast agent when CT scan was used to attenuation correction for PET images in PET/CT system. Whole body phantom was imaged with various concentration of iodine-based contrast agent using CT. Mathematical emission and transmission density map with liver were made to simulate for whole body FDG imaging. A variety of factors were estimated, including non-uniform enhancement of contrast agent, concentration and distribution size of contrast agent, noise level, image resolution, reconstruction algorithm, hypo-attenuation of contrast agent, and different time phases for contrast agent. Experimental studies showed that Hounsfield unit depends on the concentration of contrast agent and tube voltage. From the simulation data, contrast agents introduced artifacts and degraded image quality on the attenuation-corrected PET images. The severity of these effects depends on a variety of factors, including the concentration and distribution size of contrast agent, the noise levels, and the image resolution. These results indicated that the impact of contrast agents should be considered with a full understanding of their potential problems in clinical PET/CT images.

KeywordsPET/CT, Attenuation correction, Artifacts, Contrast agents

Korean Society of Medical Physics

Vol.35 No.1
March 2024

pISSN 2508-4445
eISSN 2508-4453
Formerly ISSN 1226-5829

Frequency: Quarterly

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