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Original Article

Korean Journal of Medical Physics 2013; 24(3): 154-161

Published online September 30, 2013

Copyright © Korean Society of Medical Physics.

Comparison of Intensity-modulated Radiation Therapy (IMRT), Uniform Scanning Proton Therapy (USPT), and Intensity-modulated Proton Therapy (IMPT) for Prostate Cancer: A Treatment Planning Study

전립선 암 환자의 IMRT, USPT, 및 IMPT 기법에 따른 치료효과 비교

Kihong Son*†, Seungryong Cho*, Jin Sung Kim, Youngyih Han, Sang Gyu Ju, Sung Hwan Ahn, Eunhyuk Shin, Jung Suk Shin, Won Park, Hongryul Pyo, Doo Ho Choi

손기홍*†ㆍ조승룡*ㆍ김진성ㆍ한영이ㆍ주상규ㆍ안성환ㆍ신은혁ㆍ신정석ㆍ박원ㆍ표홍렬ㆍ최두호

*Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

*한국과학기술원 원자력 및 양자공학과, 성균관대학교 의과대학 삼성서울병원 방사선종양학교실

Abstract

This study assessed compared photon and proton treatment techniques, such as intensity modulated radiation therapy (IMRT), uniform scanning proton therapy (USPT), and intensity modulated proton therapy (IMPT), for a total of 10 prostate cancers. All treatment plans delivered 70 Gy to 95% of the planned target volume in 28 fractions. IMRT plans had 7 fields for the step and shoot technique, while USPT and IMPT plans employed two equally weighted, parallel-opposed lateral fields to deliver the prescribed dose to the planned target. Inverse planning was then incorporated to optimize IMPT. The homogeneity index (HI) and conformity index (CI) for the target and the normal tissue complication probability (NTCP) for organ at risk (OAR) were calculated. Although the mean HI and CI for target were not significantly different for each treatment techniques, the NTCP of the rectum was 2.233, 3.326, and 1.707 for IMRT, USPT, and IMPT, respectively. The NTCP of the bladder was 0.008, 0.003, and 0.002 respectively. The NTCP values at the rectum and bladder were significantly lower using IMPT. Our study shows that using proton therapy, particularly IMPT, to treat prostate cancer could be beneficial compared to 7-field IMRT with similar target coverage. Given these results, radiotherapy using protons, particularly optimized IMPT, is a worthwhile treatment option for prostate cancer.

KeywordsIMRT, USPT, IMPT, Prostate cancer, Treatment planning

Korean Society of Medical Physics

Vol.35 No.1
March 2024

pISSN 2508-4445
eISSN 2508-4453
Formerly ISSN 1226-5829

Frequency: Quarterly

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