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Original Article

Korean Journal of Medical Physics 2015; 26(3): 137-142

Published online September 30, 2015

Copyright © Korean Society of Medical Physics.

Outcomes after Reirradiation for Brain Metastases

Jesang Yu, Ji Hoon Choi, Sun Young Ma, Taesig Jeung

Department of Radiation Oncology, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea

Received: September 1, 2015; Revised: September 13, 2015; Accepted: September 14, 2015

Abstract

We retrospectively analyzed the outcomes in patients who underwent reirradiation for brain metastasis. Twenty-three patients with brain metastases who were initially treated with palliative brain radiotherapy and were retreated with a second course of brain RT between June 2008 and December 2012. WBRT, 3DCRT and SRS were used for brain metastasis. The median dose of the first course of WBRT was 30 Gy (range, 23.4∼30 Gy). The dose of the first course 3DCRT for lesion was 30 Gy in 3 Gy per fraction. The median dose of the first course of SRS was 16 Gy in 1 fraction (range, 12∼24 Gy). The median dose of the second course of WBRT was 27.5 (range, 12∼30 Gy). The median dose of the second course of 3DCRT for lesion was 30 Gy (range, 25∼30 Gy). The dose of the second course of SRS was 16 Gy in 1 fraction. The second course of WBRT was administered on radiographic disease progression with symptom in all patients. With median follow-up of 25 months, overall symptom resolution rates were 47.8%. Rate of palliative efficacy was 82.6% including stable disease. The median survival time after initiation of reirradiation was 3.2 months. Median value of KPS prior to reirradiation was 30. Median value of KPS after reirradiation was 60. Reirradiation of brain metastasis maybe feasible and effective in select patients with a good performance status KPS≥60 (: ECOG 0∼2) prior to reirradiation.

KeywordsBrain metastasis,Reirradiation, Performance status, KPS

Korean Society of Medical Physics

Vol.35 No.4
December 2024

pISSN 2508-4445
eISSN 2508-4453
Formerly ISSN 1226-5829

Frequency: Quarterly

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