The purpose of this experiment is to know the relation of the detection and characterization of liver's diseases as comparison of finding at MR imaging using a Ferucarbotran (SPIO) and Gd-EOB-DTPA (Primovist) agents in diffuse liver disease. A total of 50 patients (25 men and 25 women, mean age: 50 years) with liver diseases were investigated at 3.0T machine (GE, General Electric Medical System, Excite HD) "with 8 Ch body coil for comparison of diseases and contrast's uptake relation, which used the LAVA, MGRE." All images were performed on the same location with before and after Ferucarbotran and Gd-EOB-DTPA administrations (p＜0.05). Contrast to noise ratio of Ferucarbotran and Gd-EOB-DTPA in the HCC were 3.08±0.12 and 7.00±0.27 with MGRE and LAVA pulse sequence, 3.62±0.13 and 2.60±0.23 in the hyper-plastic nodule, 1.70±0.09 and 2.60±0.23 in the meta, 2.12±0.28 and 5.86±0.28 in the FNH, 4.45±0.28 and 1.73±0.02 in the abscess and ANOVA test was used to evaluate the diagnostic performance of each disease (p＜0.05). In conclusions, two techniques were well demonstrated with the relation of the detection and characterization of liver's diseases.

KeywordsMGRE (multi-gradient-recalled echo), HCC (hepatocellular carcinoma), Ferucarbotran, LAVA (liver aquisition with volume acceleration)